Astroglial alterations from early to late stages in a model of Alzheimer?s disease: evidence of autophagy involvement in amyloid- beta internalization.

POMILIO C; GOROJOD R. M.; VINUESA A; ALAIMO A.; APARICIO E; TODERO MF; KOTLER ML; BEAQUIS J; SARAVIA F

Mar del Plata

Congreso; XXX Annual Meeting and SAN-ISN Small Conference and Course; 2015

Sociedad Argentina de Investigación en Neurociencias

Alzheimer disease (AD) is the principal cause of dementia in the elderly. Onehistopathological hallmark of AD is the presence of senile plaques, extracellular deposits principally composed of amyloid Beta (AB) peptides, which are normally surrounded by reactive glia. We studied early alterations in hippocampal astrocytes and their progression during the degenerative process in PDAPP transgenic mice, a model of AD. At 3 months of age, before plaques formation, we found less number of GFAP+ astrocytes in the stratum radiatum under CA1 (p