Astroglial alterations from early to late stages in a model of Alzheimer´s disease: evidence of autophagy involvement in amyloid- beta internalization.

POMILIO C; GOROJOD RM; VINUESA A; ALAIMO A; APARICIO E; TODERO MF; KOTLER ML; ALAIMO A., GOROJOD R.M, SIMOLA N., BEAUQUIS J., SARAVIA F., MORELLI M., KOTLER M.; SARAVIA F

Mar del Plata

Congreso; XXX Annual Meeting and SAN-ISN Small Conference and Course; 2015

SAIC

Alzheimer disease (AD) is the principal cause of dementia in the elderly. Onehistopathological hallmark of AD is the presence of senile plaques, extracellular deposits principally composed of amyloid β (Aβ) peptides, which are normally surrounded by reactive glia. We studied early alterations in hippocampal astrocytes and their progression during the degenerative process in PDAPP transgenic mice, a model of AD. At 3 months of age, before plaques formation, we found less number of GFAP+ astrocytes in the stratum radiatum under CA1 (p