IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A sequence and structure based model to explain information content relation with growth temperature 
Autor/es:
ARIEL APTEKMANN; IGNACIO SANCHEZ; ALEJANDRO NADRA
Reunión:
Congreso; VI Argentinian Conference on Bioinformatics and Computational Biology; 2015
Institución organizadora:
A2B2C
Resumen:
We previously studied the relation between optimal growth temperature (OGT) and information content (IC), in the core promoter region of all the archeal genomes published to date, by calculating the information content of the motiff that represents the TATA binding site (TBS). We tested different approaches to predict transcription start sites (TSS) in a given genome we then used motiff prediction software in the flanking regions to the TSS, we constructed a database, compiling already available information from published sources, that contains characteristic growth conditions for each strain. Our work hipotesis is that protein-dna interfase in thermophiles should be different from that of mesophiles. We propose and test a positive correlation between information content of binding sites and OGT in archeas. We show that the information content increases with increasing optimal growth temperature, and this effect cannot be explained solely by an increased CG composition.