IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
PIN-POINTING THE KEY PLAYERS IN METABOLIC REWIRING OF PROSTATE TUMOR CELLS TOWARDS PROGRESSION IN THE BONE NICHE
Autor/es:
LAVIGNOLLE, ROSARIO; BIZZOTTO, JUAN; COTIGNOLA, JAVIER; SANCHIS, PABLO; SABATER, AGUSTINA; LAGE-VICKERS, SOFIA; VAZQUEZ, ELBA; ANSELMINO, NICOLAS; LABANCA, ESTEFANÍA; NAVONE, NORA; GUERON, GERALDINE
Lugar:
Virtual
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica 2021; 2021
Institución organizadora:
SAIC
Resumen:
Metabolic rewiring is associated with the metastatic cascade, and communication between tumor cells and the bone niche is determinant for tumor progression. Here, we sought to identify key metabolic genes that fuel prostate cancer (PCa) bone metastasis. By an indirect transwell co-culture system of PCa (PC3) and bone progenitor cells (MC3T3 or Raw264.7) we assessed the transcriptomic profile of PC3 cells modulated by soluble factors released from bone precursors. Strong activation of lipid metabolic pathways including PPAR and PI3K-Akt (P
