IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Interplay between neutrophils and trophoblast cells conditions trophoblast function and triggers vascular transformation signals
Autor/es:
SABBIONE, FLORENCIA; VOTA, DAIANA; PARBORELL, FERNANDA; CALO, GUILLERMINA; KEITELMAN, IRENE; RAMHORST, ROSANNA; LEIRÓS, CLAUDIA PÉREZ; PASCUALI, NATALIA; PAPARINI, DANIEL; TREVANI, ANALÍA
Revista:
JOURNAL OF CELLULAR PHYSIOLOGY
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2020 p. 3592 - 3603
ISSN:
0021-9541
Resumen:
AbstractNormal placentation entails highly regulated interactions of maternal leukocytes withvascular and trophoblast cells to favor vascular transformation. Neutrophil activationand neutrophil extracellular trap (NET) formation associate with poor placentationand severe pregnancy complications. To deepen into the mechanisms of trophoblast?neutrophil interaction, we explored the effects of NETs on trophoblast cellfunction and, conversely, whether trophoblast cell‐derived factors conditionneutrophils to favor angiogenesis and anti‐inflammatory signals required for fetalgrowth. NETs isolated from activated neutrophils hindered trophoblast cell migration.Trophoblast conditioned media prevented the effect as well as the vasoactiveintestinal peptide (VIP) known to regulate trophoblast and neutrophil function. Onthe other hand, factors released by trophoblast cells and VIP shaped neutrophils to aproangiogenic profile with increased vascular endothelial growth factor synthesis andincreased capacity to promote vascular transformation. Results presented hereprovide novel clues to reconstruct the interaction of trophoblast cells and neutrophilsin vivo during placentation in humans.