IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi
Autor/es:
DANIEL MUSIKANT; CARLOS BUSCAGLIA; DANIEL MUSIKANT; CARLOS BUSCAGLIA; IGNACIO DURANTE; MARTIN M. EDREIRA; IGNACIO DURANTE; MARTIN M. EDREIRA; GABRIEL FERRI; DANIEL ALTSCHULER; GABRIEL FERRI; DANIEL ALTSCHULER
Revista:
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 211 p. 67 - 67
ISSN:
0166-6851
Resumen:
Mechanistic details of the modulation by cAMP of Trypanosoma cruzi host cell invasion remain ill-defined.Here we report that activation of host?s Epac1 stimulated invasion, whereas specific pharmacological inhibitionor maneuvers that alter Epac1 subcellular localization significantly reduced invasion. Furthermore,while specific activation of host cell PKA showed no effect, its inhibition resulted in an increased invasion,revealing a crosstalk between the PKA and Epac signaling pathways during the process of invasion. Therefore,our data suggests that subcellular localization of Epac might be playing an important role duringinvasion and that specific activation of the host cell cAMP/Epac1 pathway is required for cAMP-mediatedinvasion.
