CONICET | Buscador de Institutos y Recursos Humanos

Prostate cancer is one of the leading causes of men death worldwide. Several signaling pathways are highly implicated in the progression of thisdisease. Interestingly, variations in a single gene can orchestrate changes in a metabolic pathway and thus, confer an adaptive advantage. Metabolicreprogramming has emerged as one of the hallmarks of cancer and arises as consequence of changes in critical signaling pathways provoked bybalance disruption between oncogenes and tumor suppressors expression. Therefore, metabolomic analyses provide relevant information that isnot available with only genomic or proteomic studies. Noticeably, basal energetic status in luminal epithelial cells of the prostate gland contrastswith other tissues since Krebs cycle is altered so as to generate high citrate levels achieving a more glycolytic phenotype. Furthermore, the alteredsignaling pathways in prostate cancer depict changes in cellular metabolism that support the demands of rapid cell division. Particularly, metabolicpathways significantly altered in this malignancy are glutaminolysis and lipid metabolism that contribute directly to the production of acetyl-CoAand NADPH required for the synthesis of fatty acids. Therefore, deciphering the metabolic rewiring propelled by signaling pathways dysregulationis vital for the development of new therapeutic approaches in prostate cancer. Advances in these fields highlight the importance of changes inenergetic metabolism during the progression to castration resistant prostate cancer and bone metastases.