IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates.
Autor/es:
DAMONTE, E.B.; CAPEK, P.; TURJAN, J.; PUJOL, C.A.; YANBO, K.Z.
Revista:
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 87 p. 195 - 200
ISSN:
0141-8130
Resumen:
tHerpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times.4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various appli-cations in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followedby targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degreeof sulfation (10?16%) and molecular mass (21,000?5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviralactivity tests on GXS1?4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect ofall compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown tobe the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those ofheparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were activeas well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors.