IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation.
Autor/es:
DANIEL PAPARINI; GUILLERMINA CALO; ROSANNA RAMHORST; VANESA HAUK; DAIANA VOTA; ESTEBAN GRASSO; LUCILA GALLINO; CLAUDIA PEREZ LEIROS
Revista:
CELL ADHESION AND COMMUNICATION
Editorial:
Landes Bioscience
Referencias:
Año: 2016
ISSN:
1061-5385
Resumen:
Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the recruitment of different leukocyte populations to generate the maternal-placental interface, but also constitutes an additional checkpoint for tissue homeostasis maintenance. The normal switch from a pro-inflammatory to an anti-inflammatory predominant microenvironment characteristic of the post-implantation stage requires redundant immune tolerance circuits triggered by key master regulators. In this review we will focus on the recruitment and conditioning of maternal immune cells to the uterus at the early implantation period with special interest on high plasticity macrophages and dendritic cells and their ability to induce regulatory T cells. We will also point to putative immunomodulatory polypeptides involved in immune homeostasis maintenance at the maternal-placental interface.