Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities

RAY, S.; PUJOL, C.A.; DAMONTE, E.B.; RAY,B.

CARBOHYDRATE POLYMERS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2015

0144-8617

Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans withbiological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide-sulfate/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one step procedure has the power of providing a spectrum of xylomannans with varying molecular masses, sulfate content and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound and in the absence of drug-induced cytotoxicity. Regarding methodological facet,the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular massand sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources.