Enhanced Analytical Performance of Paper Microfluidic Devices by Using Fe3O4 Nanoparticles, MWCNT, and Graphene Oxide.

FEDERICO FIGUEREDO; PAULO T. GARCIA; EDUARDO CORTÓN; WENDELL K. T. COLTRO

ACS APPLIED MATERIALS & INTERFACES

AMER CHEMICAL SOC

Lugar: Washington; Año: 2015

1944-8244

Spheres, tubes, and planar-shaped nanomaterialsas Fe3O4 nanoparticles (MNPs), multiwalled carbonnanotubes (MWCNT), and graphene oxide (GO) were usedfor the first time to treat microfluidic paper-based analyticaldevices (μPADs) and create a biocompatible layer with highcatalytic surface. Once glucose measurements are critical fordiabetes or glycosuria detection and monitoring, the analyticalperformance of the proposed devices was studied by usingbienzymatic colorimetric detection of this carbohydrate. Thelimit of detection values achieved for glucose with μPADstreated with MNPs, MWCNT, and GO were 43, 62, and 18μM, respectively. The paper surface modification solvesproblems associated with the lack of homogeneity on color measurements that compromise the sensitivity and detectabilitylevels in clinical diagnosis.