Eryptosis is induced by hyperthermia in hereditary spherocytosis red blood cells.

CRISP R; VOTA DM; DONATO H; GARCIA E ; RAPETTI MC; MALTANERI RE; VITTORI DC; NESSE AB

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

WALTER DE GRUYTER & CO

Lugar: Berlin; Año: 2015

1434-6621

In pediatric hereditary spherocytosis (HS) patients, anemiafrequently worsens throughout the course of infectiousdiseases, due either to increased hemolysis or to transitoryerythropoietic aplasia [1]. Hemolysis may be so importantthat even asymptomatic individuals can incidentally bediagnosed with HS during a hemolytic crisis secondary tofebrile disease [2]. It has been reported that HS children,especially those under 6 years old, frequently suffer hemolyticcrises triggered by viral infections [2?4]. These reports,along with usual clinical practice, suggest a potentialharmful effect of temperature on erythrocytes which mayaffect their survival.Increasing evidence is now available to demonstratethat erythrocytes can also undergo premature self-destructionthrough a mechanism known as eryptosis, whichshares several features with nucleated-cell apoptosis.Since this process may be accelerated by different environmentalfactors, we decided to study whether hyperthermia?per se? has a direct effect on HS erythrocytes.