IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Partial and total C-6 oxidation of gelling carrageenans. Modulationof the antiviral activity with the anionic character
Autor/es:
COSENZA, VA; NAVARRO, DA; PUJOL, CA; DAMONTE, EB; STORTZ, CA
Revista:
CARBOHYDRATE POLYMERS
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 128 p. 199 - 206
ISSN:
0144-8617
Resumen:
tThe optimal conditions for the full C-6 oxidation of - and -carrageenans using (2,2,6,6-tetramethylpiperidinyl)oxy (TEMPO) in the presence of sodium hypochlorite and sodium bromide wereassessed. The fully oxidized products were characterized by NMR spectroscopy. Partially oxidized prod-ucts were also obtained and analyzed by chemical and spectroscopical methods. The antiviral activity ofcarrageenans against herpes simplex virus HSV-1 and HSV-2 determined by plaque reduction assay, wasnot largely affected by full oxidation of the polysaccharides, but an increase in activity was detected bypartial oxidation. A specific overoxidation on C-2 of the 3,6-anhydrogalactose moiety of -carrageenanwas identified, solved experimentally and rationalized through the application of molecular modeling.
