IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Neuroimmune Aspects of Sjögren?s Syndrome: Role of VIP/VPAC System in Immune and Salivary Gland Epithelial Cell Function
Autor/es:
HAUK V, CALAFAT M,; GRASSO E, FRACCAROLI L, ; PAPARINI D; RAMHORST R; PEREZ LEIROS C
Revista:
CURRENT PHARMACEUTICAL DESIGN.
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Seattle; Año: 2014 vol. 20 p. 4760 - 4765
ISSN:
1381-6128
Resumen:
Sjögren syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular pathways involved in gland homeostasis loss and the autoimmune response are focused in the search of novel drug targets and biomarkers. Vasoactive intestinal peptide (VIP) has trophic, pro-secretory and immunomodulatory effects in several chronic and autoimmune disease models. Here we review evidence pointing to its role as an endogenous modulator of gland homeostasis at early stages of the disease. Particularly, mechanisms involving VIP/VPAC system in the course of salivary function impairment in the non obese diabetic (NOD) mouse model of Sjögren?s syndrome are described.