IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Involvement of galectin-1 in reproduction: past, present and future
Autor/es:
BARRIENTOS, G; FREITAG, N; TIRADO-GONZÁLEZ, I; UNVERDORBEN, L; JESCHKE, U; THIJSSEN, VL; BLOIS, SM
Revista:
HUMAN REPRODUCTION UPDATE.
Editorial:
OXFORD UNIV PRESS
Referencias:
Lugar: Oxford; Año: 2014 vol. 20 p. 175 - 193
ISSN:
1355-4786
Resumen:
BACKGROUND After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal?maternal interface, many functional aspects of this lectin in reproduction are only emerging. METHODS The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal?fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. RESULTS This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation. We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytium formation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. CONCLUSION The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy.