IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Protein tyrosine phosphatase 1b (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin
Autor/es:
CHAMORRO MARÍA EUGENIA; MALTANERI ROMINA EUGENIA; VITTORI DANIELA; NESSE, ALCIRA
Revista:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELLULAR BIOLOGY
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 61 p. 63 - 71
ISSN:
1357-2725
Resumen:
Highlights ? Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells. ? cEpo induced only transient phosphorylation of proliferative pathways. ? PTP1B activity was significantly increased in cultures with cEpo. ? PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo. ? Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.
