CONICET | Buscador de Institutos y Recursos Humanos

tDe novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory sett-ings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necroticcells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cellsinteracted with recruited inflammatory and T cells. In this work we report for the first time the recruit-ment of two morphologically different CD207+cells to vaccination site. The time-course behavior ofCD207+cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6?10 days,CD207+cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNswere enriched in a peculiar MHCII+CD11c(−)CD207+population, whose role remains to be determined.Whether CD207+cells migration to the vaccination site can be associated with a differential anti-tumoralresponse remains as an open and exciting question.De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory sett-ings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necroticcells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cellsinteracted with recruited inflammatory and T cells. In this work we report for the first time the recruit-ment of two morphologically different CD207+cells to vaccination site. The time-course behavior ofCD207+cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6?10 days,CD207+cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNswere enriched in a peculiar MHCII+CD11c(−)CD207+population, whose role remains to be determined.Whether CD207+cells migration to the vaccination site can be associated with a differential anti-tumoralresponse remains as an open and exciting question.