IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Tumor-specific MAGE proteins as regulators of p53
Autor/es:
20. M.F.LADELFA, L.Y.PECHE, M.F. TOLEDO, J.E. LAISECA, C.SCHNEIDER, M. MONTE
Revista:
CANCER LETTERS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 325 p. 11 - 17
ISSN:
0304-3835
Resumen:
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I)family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor.In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
