IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all New World hemorrhagic fever arenaviruses
Autor/es:
HELGUERA G.; JEMIELITY S.; ABRAHAM J.; CORDO S.; MARTINEZ G.; RODRÍGUEZ J. A.; BREGNI C.; WANG J. J.; FARZAN M.; PENICHET M. L.; CANDURRA N.; CHOE H.
Revista:
JOURNAL OF VIROLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2012 vol. 86 p. 4024 - 4028
ISSN:
0022-538X
Resumen:
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.
