IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
Autor/es:
PUJOL, C.A.; RAY, S.; RAY, B.; DAMONTE, E.B.
Revista:
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 51 p. 412 - 416
ISSN:
0141-8130
Resumen:
Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia
indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatumGrateloupia
indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum
and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for
antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible
serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.1220 g/mL. The
antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate
group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral
effect was mainly exerted during DENV-2 adsorption and internalization.Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for
antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible
serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.1220 g/mL. The
antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate
group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral
effect was mainly exerted during DENV-2 adsorption and internalization.
© 2012 Elsevier B.V. All rights reserved.