Development of a new antimicrobial agent with a promising use in wound healing management

PAEZ, PAULINA; GRANERO, G.; ONNAINTY, RENÉE; USSEGLIO, NADINA; CARRER, D. C.; PAEZ, PAULINA; GRANERO, G.; ONNAINTY, RENÉE; USSEGLIO, NADINA; CARRER, D. C.

Mar del Plata

Congreso; Reunion de Sociedades de Biociencia 2019; 2019

SAIC, SAFE, y otras

In the vast world of medicine there are severalfields of study of interest; one of them is wound healing. Wounding leads toexposure of subcutaneous tissue that provides a nutritious environmentconductive to microbial colonization and proliferation. The presence ofbacteria at the wound site down regulates the host immune response, ultimatelydelaying the natural wound healing process, making the total healing timeunpredictable. The usefulness of silver as an antimicrobialagent has been known for a long time. It´s especially important in the topicalantibacterial treatment of burn wounds. The most widely use reagents have beensilver nitrate and silver sulfonamides. However, they have showed a limitedclinical usefulness.The aim of this work is to develop a newwater-soluble silver complex formed with triethanolamine (TEA) and silver nitrate(AgNO3) for use in wound healing treatment. The antimicrobial activity of the developedsilver complex was tested against S.aureus by determining its Minimum Inhibitory Concentration (MIC). Thepotential cytotoxicity effect was assessed in vitro against L929 fibroblasts.Antimicrobial results showed that the silver complexdisplays effective antimicrobial activity comparable to MIC values of AgNO3.This study sets a platform for further work forthe use of the novel developed silver complex from the wound care applicationperspective.