Microbiological and physicochemical studies of ketokonazole:b-cyclodextrin:citric acid multicomponent inclusion compounds

M. LONGHI; A. ZOPPI; V. AIASSA; A. BRUNO

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedades de Biociencias de Argentina

Candida is an opportunistic yeast that causes severe diseases in immunocompromised individuals such as undergoing immunosuppressive therapy for cancer or organ transplantation and in patients with AIDS1. Ketoconazole (KET) is an antifungal agent suitable for the treatment of candidiasis and other systemic fungal infections2, classified as a class II drug in the Biopharmaceutics Classification System because of its low solubility and high permeability. Cyclodextrins (CD) multicomponent complexation is used to improve the poor aqueous solubility of different drugs3. Different molecules can penetrate into the relatively hydrophobic cavity and form non-covalent inclusion complexes, thus modifying their physical, chemical and biological properties . As citric acid (CA) is a pH-modifier used to increase solubility of weakly basic compounds, the aim of this work was to assess the effect of KET:βCD:CA multicomponent complexation in the solubility and antifungal activity of KET against C. albicans and C. parapsilosis.