Enhanced solubility and antibiofilm activity of rifampicin by complexation with β-cyclodextrin and arginine

A. DAN CORDOBA; A. ZOPPI; V. AIASSA; M. LONGHI

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedades de Biociencias de Argentina

Biofilms are highly organized bacterial communities with functional heterogeneity that are formed on biotic and abiotic surfaces. They protect bacteria from the harsh external environment via self produced matrices of extracellular polymeric substances. They are also more resistant to antimicrobial agents than the same bacteria growing in a free swimming state. Rifampicin (RIF, Fig. 1) is an antibiofilm antibiotic, which is able to attack the Staphylococci in biofilm, but the effectiveness of this drug is hampered by its limited solubility at neutral pH and its variable bioavailability. The objective of this study was to improve the solubility and antibiofilm activity of RIF by multicomponent complex (MC) formation with β-cyclodextrin (β-CD) and Arginine (ARG).