Development of self-microemulsifing drug delivery systems to Increase the oral bioavailability of resveratrol

MS. BUENO; M. LONGHI; C. ALOISIO; S. D. PALMA

Rosario

Congreso; 4a Reunión Internacional de Ciencias Farmacéuticas (RiCIFA).; 2016

Universidad Nacional de Rosario

The aim of this work was the development of solid Self-Microemulsifing Drug Delivery Systems (SMEDDS) to improve the oral bioavailability of Resveratrol (RES). These, once dispersed in an aqueous media with mild agitation, form microemulsions (ME). Therefore, after their administration and dispersion in the gastric fluids, ME formation is assisted by peristaltic movements of the gastrointestinal tract. Recently, numerous studies suggested that RES possesses anti-inflammatory, anti-cancer, anti-amyloid and antioxidant properties. However, the therapeutic applications remain limited due to poor solubility of RES, meaning low bioavailability.