Evaluation of binary and ternary systems on biopharmaceutical properties of furosemide

C. GARNERO; M. LONGHI; V. STERREN; J. ABRAHAM-MIRANDA; A. ZOPPI

Rosario

Congreso; 4a Reunión Internacional de Ciencias Farmacéuticas (RiCIFA).; 2016

Universidad Nacional de Rosario

Currently, supramolecular chemistry is intensely applied in the pharmaceutical industry with the purpose of optimizing the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (IFA). It is known that binary and ternary systems, salts, cocrystals and amorphous solids are able to modify properties as solubility, dissolution rate and permeability. An IFA commonly used in the treatment of hypertension and edema is furosemide (FUR), which has highly variable oral bioavailability in humans due to its low solubility and permeability adding to its site-specific absorption in the stomach and upper small intestine. Previous studies revealed that triethanolamine (TEA) is a permeation enhancer, while β-cyclodextrin (β-CD) and maltodextrin (MD) showed capacity to increment solubility and dissolution rate of FUR.1,2 In this study, with the aim of improving FUR dissolution were prepared binary and ternary systems and was analyzed their effect on this property.