UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Development of self-microemulsifing drug delivery systems to Increase the oral bioavailability of resveratrol
Autor/es:
PALMA S.; ALOISIO, C.; BUENO M.S.; LONGHI M.R
Lugar:
Rosario
Reunión:
Congreso; 4a Reunión Internacional de Ciencias Farmacéuticas (RICiFA).; 2016
Institución organizadora:
Facultad de Farmacia y Bioquímica, Universidad Nacional de Rosario
Resumen:
The aim of this work was the development of solid Self-Microemulsifing Drug Delivery Systems (SMEDDS) to improve the oral bioavailability of Resveratrol (RES). These, once dispersed in an aqueous media with mild agitation, form microemulsions (ME). Therefore, after their administration and dispersion in the gastric fluids, ME formation is assisted by peristaltic movements of the gastrointestinal tract.[1,2] Recently, numerous studies suggested that RES possesses anti-inflammatory, anti-cancer, anti-amyloid and antioxidant properties. However, the therapeutic applications remain limited due to poor solubility of RES, meaning low bioavailability.[3] SMEDDS were obtained from ME containing cod liver oil as the oil phase (O), buffer of pH 7.4 as the aqueous phase (W) and soy phosphatidylcholine (SPC)/ Eumulgin® HRE40 (EU)/sodium oleate (SO) for ME A, SFC/Tween®80 (TW)/SO for ME B or FCS/EU/TW for ME C, as surfactant mixture (S). From Pseudo-ternary Phase Diagrams, a wide range of combinations, to prepare transparent O/W ME, was observed. High RES concentrations were possible to be incorporated, especially when ME C was utilized (21.26 mg/mL). Solid SMEDDS were obtain by spray-drying, with the largest yield percentage acquired when anhydrous silicic acid (ASA) was used as adsorbent (80.12 %). This may be due to the surface modification to hydrophilic, that reduced the cohesive force between the drug particles. The systems presented appropriated sizes (~1μ) after reconstitution, demonstrating self microemulsifing ability. Significant enhancements in RES dissolution were observed from the solid SMEDDS, with a maximum of 83% at 7 h obtained with SMEDDS C. From these results, the developed systems result promising to improve the oral bioavailability of RES and other hydrophobic drugs.References1. Sprunk A, et al. Eur J Pharm Sci 2012;46(5):508?15. 2. Mekjaruskul C, et al. Int J Pharm 2013;445(1-2):1?11. 3. Sandhir R, et al. Neurochem Int 2015;89:209?26.