UNITEFA 23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Development and Characterization of Dexamethasone-Loaded Crosslinked Hyaluronic Acid Films for Ocular Therapy
Autor/es:
CALLES, JAVIER ADRIÁN; LOPEZ-GARCÍA, ANTONIO; PALMA, SANTIAGO DANIEL; VALLÉS, ENRIQUE MARCELO; DIEBOLD, YOLANDA
Lugar:
Edimburgo
Reunión:
Congreso; 2015 CRS Annual Meeting; 2015
Institución organizadora:
Control Release Society
Resumen:
The aim of this work was the design and characterization of crosslinked hyaluronic acid (HA)-itaconic acid (IT) films loaded with dexamethasone (DEX) for topical therapy of inflammatory ocular surface diseases.Films were chemically crosslinked with polyethyleneglycol diglycidyl ether (PEGDE); then physical and mechanical characterization by stressstrain, x-ray diffraction, x-ray fluorescence spectrometry, and swelling assays was conducted.An in vitro therapeutic efficacy model was designed to assess IL-6 production in an inflamed human corneal epithelial (HCE) cell line after film exposure.
