CONICET | Buscador de Institutos y Recursos Humanos

The permeability and solubility of some drugs can be limiting conditions for oral absorption with the consequent decrease of bioavailability. Solids dispersions (SDs) have been proposed as alternative for improvement of dissolution rate of different drugs using carriers like poloxamer. The aim of this work was to increase the dissolution rate of Albendazole (ABZ) through its incorporation in SDs using Poloxamer 407 (P407) as carrier, by means of the study of the pharmacotechnical properties of the prepared formulations. In all prepared formulations (5, 10, 25 and 50 % w/w) it is shown an improvement of dissolution rate while the concentration of P407 decreases. In SDs with lower P407 percentage (SD3 and SD4) reaches nearly 60% of dissolved ABZ during the initial stage while SD1 and SD2 hardly reaches 20%. This effect can be explained because when SDs upon contact with the dissolution medium at 37°C, P407 would form a gel-layer in the particles surface that can be able to modulate the release of ABZ. Physical mixtures (PMs) were prepared from the studied formulations, showing a different behavior to the SDs. This is possible because they are mechanical mixtures, the ABZ particles can be distributed in a non uniform way in the dissolution medium. Although P407 contributes to increase the dissolution rate of ABZ it is not done in function of the proportion that it is in the system. ABZ (pure drug) and PMs have very poor flow properties. However, this property is improved when the drug is incorporated in the SDs. For example the angle of repose of the MF4 was 57 ± 1 while for DS4 was 34 ± 2. The addition of P407 as carrier in SDs containing ABZ markedly improves its dissolution properties. SDs seem to be advantageous over PMs for manufacturing of acceptable quality solid dosage forms.