Pharmaceutical composition and pharmacological treatment for enhancement of methadone analgesia and prevention of methadone tolerance.

ROMAÑUK CAROLINA BEATRIZ; MANZO RUBEN HILARIO; LAINO CARLOS HORACIO; OLIVERA MARIA EUGENIA

Washington

Congreso; TechConnect World 2014- National Innovation Summit & Showcase.; 2014

TechConnect

This innovative technological development includes a pharmaceutical composition which combines Omega 3 fatty acids with Methadone, and a pharmacological treatment related to its use. Omega 3 fatty acids are natural products already approved for its use in humans. Methadone is also an approved drug. Therefore, many expensive and time consuming clinical trials required for proving efficacy and toxicity could be avoided. This development is under patent application in Argentina and the know-how is available for transfer to the pharmaceutical industry. Its main advantage is that pain management can be achieved with sub-therapeutic doses of the opioid allowing a reduction/avoidance of side effects. Also, a decrease in the tolerance analgesic effect is observed. Our proposal could be useful for pain management in conditions related to both malignant and non-malignant pain. So, a big target population could be favored with this innovation. Our proposal is of interest for pharmaceutical companies who commercialize opioids or omega 3 fatty acids and/or those who manufacture soft capsules.