Development of new hydrochlortiazide:chitosan nanoparticles

R. ONNAINTY; M. LONGHI; G. GRANERO

Cordoba

Congreso; 3a Reunión Internacional de Ciencias Farmacéuticas; 2014

Universidad Nacional de Córdoba

Nanoparticles (NPs) are frequently defined as solid, colloidal particles in the range 10 ? 1000 nm. Chitosan (CHI) is a linear polysaccharide composed of D-glucosamine and N-acetyl-D-glucosamine. Low molecular weight (LMW) CHI shows better solubility, biocompatibility, bioactivity, biodegradability and even less toxicity than other kind of CHI. Hydrochlorotiazide (HCT) is a diuretic class of thiazides. This drug is poorly soluble in water and slightly permeable through intestinal mucosa.