Biocompatible and bioadhesive films based on polyelectrolyte-drug complexes using novel dendronized chitosan loaded with Ciprofloxacino

GARCÍA, MC.; ALDANA, A.; MARTINELLI, M.; JIMENEZ-KAIRUZ, AF.

Córdoba

Congreso; 3º Reunión Internacional de Ciencias Farmacéuticas-RICiFa; 2014

The use of polymeric films as topical controlled drug delivery systems is an interesting alternative to conventional treatments. New dendronized chitosan derivatives (WChi) were synthesized as biomaterials with improved mechanical properties.(1) The aims of this work were the preparation of film based on Chi-Ciprofloxacino ionic complexes (Chi-Cip) and the in vitro evaluation of relevant biopharmaceutical behaviours. An appropriate Chi and Weisocyanate-Chi (WChi) were partially (50%) neutralized with Cip, in aqueous dispersions. Polyvinyl-pyrrolidone (PVP) 1% as plasticizer was added. Films based in Chi-Cip complexes were obtained by solvent casting at 40ºC for 24h using a Petri dish. Dried hydrogel films were appropriate cutted into 5-mm diameter disks. The Cip content and uniformity was assayed. In vitro release studies towards buffer solution pH 5.8 and 7.4, using Franz cell?s were performed and bioadhesion studies on mucin gel layer (30%). Release profiles were analyzed using Zero order, Higuchi and Peppas equations. The Cip content and uniformity was demonstrated, (2.2±0.2) and (1.9±0.2) μg.cm-2 of Cip into Chi and WChi films, respectively. Release profiles showed a slow and controlled Cip release rate (Q24h>70% and Q24h