Novel poly(NIPA-co-AAc) functional hydrogels with potential application in oral drug controlled release

CUGGINO, J.; CONTRERAS, C.; JIMENEZ KAIRUZ, AF.; MALETTO, BELKIS; ALVAREZ IGARZABAL, C.

Porto Galinhas

Congreso; XIV Latin American Symposium on polymers; 2014

Associacion Brasileira de Polímeros

The synthesis, characterization and properties of pH / thermo-sensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N′-diallyltartramide (DAT) as crosslinking agent and water as solvent, are presented in this work. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media which give to these new materials potential applications as carrier in smart oral drug delivery formulations.