UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Sodium Hyaluronate Minitablets for Ocular Therapy
Autor/es:
CALLES JAVIER ADRIÁN, ; UZAL IÑAKI,; PALMA SANTIAGO DANIEL, ; VALLÉS ENRIQUE MARCELO
Lugar:
Córdoba
Reunión:
Congreso; Tercera Reunión Internacional de Ciencias Farmacéuticas - RICIFA 2014; 2014
Institución organizadora:
Facultad de Ciencias Quimicas - UNC
Resumen:
Introduction: Topical administration is preferred for ocular drug delivery to the structures of the front part of the eye, such as the cornea and the conjunctiva. Traditional ocular topical dosage forms have limitations in solving many eye diseases. The main reason could be attributed to the rapid and extensive drainage loss of the formulation in the precorneal area as a result of blinking and tear replacement. A promising alternative to increasing the residence time of formulations in the area of application is the use of bioadhesive systems capable of releasing controlled amounts of the desired drug. In this work we propose the design of minitablets (MTs) for topical ophthalmic application; using hyaluronic acid, a well-known biomaterial widely used in ophthalmology, and hydroxypropyl methylcellulose, an excipient widely used in pharmaceutical industry for oral, ophthalmic and skin formulations. MTs loaded with timolol maleate (TM) were prepared by direct compression method and characterized in terms of the rheology of powders, crushing strenght, friability and drug delivery. Results: Studies showed limited flow properties in powder mixture. Angle of Repose values are slightly higher than 34º, Compressibility Index higher than 21 and Hausner Ratio superior to 1,25 (higher aceptable values for each index). On the other hand strenght, frability and release assays showed good performance. Crushing strenght values were 26,6 ± 1,25 N and the friability 0,403%. Finally drug release showed a slow release ratio, reaching the 80% of TM loaded in 4 h. Conclusions: New MTs designed showed slow release ratio for TM, low strenght but good frability. However the formulation must be optimized in order to reach better flow properties of poder mixture. Acknowledgments: Authors want to thanks National Research Council of Argentina, National University at Bahía Blanca and National University of Córdoba for financial support. Keywords: minitablets ? hyaluronan ? ocular ? glaucoma.