IMPROVING DELIVERY SYSTEMS THROUGH SUPRAMOLECULAR COMPLEXES OF MALTODEXTRIN OR CLYCLODEXTRIN AND FUROSEMIDE POLYMORPHS

A. K. CHATTAH; M. R. LONGHI; C. GARNERO

Rio de Janeiro

Encuentro; 18th ISMAR Meeting; 2013

Associação de Usuários de Ressonância Magnética Nuclear

Furosemide (FUR) is a loop diuretic used in the oral treatment of edematous states, which has seven polymorphic forms. FUR is practically insoluble in water . Two critical factors responsible for the poor and highly variable human bioavailability of FUR are its low permeability and solubility. Maltodextrins (MD)and cyclodextrins (CD), obtained from the partial hydrolysis of starch with suitable enzymes, have the capability of complexation to various compounds with the host-guest one being the most common interaction. This work is focused on prepare and characterize new supramolecular systems of two polymorphs of FUR (I and II) with MD and CD, considering that a strategy widely used to increase the solubility of drugs is the complex formation, and that to control the selection of a proper polymorph has a great impact in pharmaceutical industry.