UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Preparation and characterization of sulfamethazine multicomponent complexes
Autor/es:
A. ZOPPI; M. LONGHI
Lugar:
Brasilia
Reunión:
Congreso; ? V Congreso Iberoamericano de Ciencias Farmacéuticas, XV Conferencia Iberoamericana de Facultades de Farmacia (COIFFA).; 2013
Institución organizadora:
Conferenferencia Iberoamericana de Facultades de Farmacia
Resumen:
Sulfamethazine (SMT) is a drug used in the treatment of infections arising from Gram-positive and Gram-negative organisms. However, the water solubility of SMT is low and consequently reduces its bioavailability.1 The complexation with â-cyclodextrin (âCD) in presence of auxiliary substances is a commonly applied approached to increase the solubility of a poorly soluble compounds.2 Based on the above-mentioned considerations, the aim of the present series of experiments was to investigate the combined effect of âCD and different amino acids [arginine (Arg), aspartic acid (Asp), glutamic acid (Glu), isoleucine (Ile), leucine (Leu) and valine (Val)] on the enhancement of SMT aqueous solubility.