Improving delivery systems through supramolecular complexes of maltodextrin or cyclodextrin and furosemide polymorphs

A. CHATTAH; M. LONGHI; C. GARNERO

Rio de Janeiro

Congreso; 18th ISMAR Meeting, 14th NMR Users Meeting, V Iberoamerican NMR Meeting Biomedical Imaging Symposium; 2013

International Society of Magnetic Resonance

Furosemide (FUR) is a loop diuretic used in the  oral treatment of edematous states, which has seven polymorphic forms. FUR is   practically  insoluble in water . Two critical factors responsible for the poor and highly variable human bioavailability of FUR are its low permeability and solubility. Maltodextrins (MD)and cyclodextrins (CD), obtained from the partial hydrolysis of starch with suitable   enzymes, have the capability of complexation to various compounds with the host-guest one being the  most common interaction.  This work is focused on prepare and characterize new supramolecular systems of two polymorphs of FUR (I and II) with MD and CD, considering that a strategy widely used to increase the solubility of drugs is the complex formation, and that to control  the selection of a proper polymorph  has a great impact in pharmaceutical industry.