Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

BUENO, MARÍA SOLEDAD; PALMA, SANTIAGO DANIEL; BUENO, MARÍA SOLEDAD; PALMA, SANTIAGO DANIEL; ALOISIO, CAROLINA; PAREDES, ALEJANDRO; ALOISIO, CAROLINA; PAREDES, ALEJANDRO; PONTE, MICAELA PONCE; LONGHI, MARCELA; PONTE, MICAELA PONCE; LONGHI, MARCELA

Therapeutic Delivery

Future Science

Lugar: Londres; Año: 2019 vol. 10 p. 626 - 641

2041-5990

A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin® HRE-40 (EU)/Sodium oleate (system A); SPC/Tween®80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.