UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
artículos
Título:
Halogenated phenotiazine as photoantimicrobial agent against Staphylococcus aureus. Evaluation of the vehiculization in polymeric nanoparticles
Autor/es:
VARA, J.; IGARZABAL, C.I. ALVAREZ; PEREYRA, L.; ORTIZ, C.S.; GUALDESI, M.S.; AIASSA, V.
Revista:
DYES AND PIGMENTS
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2019
ISSN:
0143-7208
Resumen:
A thiazine derivative of AzB, the monoiodinated Azure B (AzBI), was designed, characterized, chemical andphotochemically evaluated, and screened for antibacterial activity.The monoiodinated derivative showed better chemical and photochemical properties compared to the leadingcompound Azure B (AzB). Also, AzBI exhibited good antibacterial activity against methicillin-sensitiveStaphylococcus aureus (MSSA) ATCC 29213 and methicillin-resistant S. aureus (MRSA) ATCC 43300. The assayedcompound represents a promising structure for the development of a new synthetic photosensitizer with improved properties and biological activity.Based on the results obtained for AzBI, this compound was loaded in the polymeric nanoparticles synthesizedby our working group in order to improve some of its physicochemical properties. In this way, it was possible tosuccessfully load the monoiodinated derivative and yield a promising drug transport system. The latter presentedbetter characteristics and antimicrobial activity than AzBI against the different strains tested. All these resultsmake AzBI an excellent candidate for application in photodynamic therapy.