Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin

PAREDES, ALEJANDRO J.; ALLEMANDI, DANIEL A.; MONTENEGRO, MARIANA A.; ROSSI, YANINA E.; BORSARELLI, CLAUDIO D.; ROSSI, YANINA E.; BORSARELLI, CLAUDIO D.; VANDEN BRABER, NOELIA L.; PORPORATTO, CARINA; CORREA, SILVIA G.; VANDEN BRABER, NOELIA L.; PORPORATTO, CARINA; CORREA, SILVIA G.; PAREDES, ALEJANDRO J.; ALLEMANDI, DANIEL A.; MONTENEGRO, MARIANA A.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ELSEVIER SCIENCE BV

Año: 2018 vol. 112 p. 399 - 404

0141-8130

The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinkedmicrocapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) aswall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-dryingtechnique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5ìm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, beingthe release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almostdouble than thosemadewith Ch under gastric conditions, but the samerelease ratewas observed for both Qr-MCunder intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) includinghydroxyl radical HO?, anion superoxide O2 ?− and singlet oxygen 1O2 was observed, indicating that Ch biopolymersare also suitable functional coating materials for flavonoid microencapsulation, regarding the gastroresistance, antioxidant activity and controlled release properties that could increase the bioavailability of theflavonoid.