Comparison of two experimental models of glaucoma in rabbits

TARTARA, LI; ALLEMANDI, D; LEAVI, S; PALMA, S; CAMPANA, V

revista de la facultad de ciencias medicas

FCM.UNC

Lugar: CORDOBA; Año: 2018 vol. 75 p. 25 - 31

0014-6722

OBJECTIVE:to compare two models of experimental glaucoma by induction of ocular hypertension in rabbits.MATERIALS AND METHODS:Sixteen New Zealand female rabbits, 2-3 kg were used. Model A (n=6): cauterization of episcleral and perilimbar veins of the right eye (RE) with surgical electrocautery. Model B (n=10): Injection of ?-chymotrypsin in posterior chamber of RE. Intraocular pressure (IOP) was measured before and after the induction of ocular hypertension (OHT), once a week at the same time of day for 40 days, with a manual tonometer. The animals were euthanized by CO2 inhalation. In both models the control was the IOP of the left eye (LE). The mean and standard error (SE) values of IOP, expressed in mmHg, were compared statistically by applying Student's t-test with a significance level of p