UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
artículos
Título:
On the Production of Chitosan-Coated Polycaprolactone Nanoparticles in a Confined Impinging Jet Reactor
Autor/es:
BARRESI, ANTONELLO A.; MORA, MARIA JULIA; FISSORE, DAVIDE; ZELENKOVÁ, TEREZA; GRANERO, GLADYS ESTER
Revista:
JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2017 vol. 107 p. 1157 - 1166
ISSN:
0022-3549
Resumen:
This work is focused on the synthesis of polycaprolactone nanoparticles, coated with chitosan, in aconfined impinging jet reactor using the solvent displacement method. The role of the various reactingspecies was investigated, evidencing that a biocompatible polymer, for example, polycaprolactone, isrequired to support chitosan to obtain a monomodal particle size distribution, with low particle diameters.A surfactant is required to reduce the nanoparticle size (down to a mean diameter of about 260nm) and obtain a positive zeta potential (about þ31 mV), perfectly suitable for pharmaceutical applications.Different surfactants were tested, and Poloxamer 388 appeared to be preferable to polyvinylalcohol. The effect of the concentration of Poloxamer 388 (in the range 0.5-5 mg mL1) and of chitosan(in the range 1.5-5 mg mL1) on both the mean particle size and zeta potential was also investigated,evidencing that chitosan concentration has the strongest effect on both parameters. Finally, the effect ofsolvent evaporation, quenching and feed flow rate was investigated, showing that the evaporation stagedoes not affect particle characteristics, quenching is required to avoid particle aggregation, and a minimumliquid flow rate of 80 mL min1 is required in the considered reactor to minimize the particle size.