UNITEFA 23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
artículos
Título:
Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment
Autor/es:
CERIZE, NATALIA N.P.; PACHIONI-VASCONCELOS, JULIANA A.; VALENZUELA-OSES, JOHANNA K.; BASSÈRES, DANIELA S.; GOMES-FILHO, SANDRO M.; GARCÍA, MÓNICA C. (SHARED FIRST AUTHORSHIP); RANGEL-YAGUI, CARLOTA O.; LOURENÇO, FELIPE R.; FEITOSA, VALKER A. (SHARED FIRST AUTHORSHIP)
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2017 vol. 81 p. 327 - 333
ISSN:
0928-4931
Resumen:
Miltefosine presents antineoplastic activity but high hemolytic potential. Its use in cancer has been limited to treating cutaneous metastasis of breast cancer. To decrease hemolytic potential, we developed a formulation of miltefosine-loaded polymeric micelles (PM) of the copolymer Pluronic-F127. A central composite design was applied and the analysis of variance showed that the optimum level of hydrodynamic diameter and polydispersity index predicted by the model and experimentally confirmed were 29nm and 0.105, respectively. Thermal analyses confirmed that miltefosine was molecularly dispersed within PM. Pluronic-F127 PM with miltefosine 80μM presented a significant reduction of hemolytic effect (80%, p
