Synthesis and Physicochemical Properties of Polyacrylamide Nanoparticles as Photosensitizer Carriers.

GUALDESI M.S.; ALVAREZ IGARZABAL C.I.; VARA J.; ORTIZ C.S.; GUALDESI M.S.; ALVAREZ IGARZABAL C.I.; VARA J.; ORTIZ C.S.

INTERNATIONAL JOURNAL OF PHARMACEUTICS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 512 p. 213 - 218

0378-5173

At present, polyacrylamide nanoparticles are attractive to drug delivery. However, some physicochemical characteristics of these nanoparticles still need to be further improved in practice. Polyacrylamide nanoparticles with an average size of 80 nm and a zeta potential of 30 mV were synthesized and used as photosensitizer carriers. The new monobrominated derivatives and parent compounds were the photosensitizers for the photodynamic therapy loaded in the nanocarrier. The physicochemical characterization of the prepared nanoparticles, drug loading, the ability to generate singlet oxygen and chemical stability were investigated. The novel tested nanoparticles exhibited a loading percentage of between 80 and 99%, higher generation of singlet oxygen and good stability in comparison with the corresponding starting reagent. According to these results, the novel polyacrylamide nanoparticles are excellent candidates for drug vehiculization.