UNITEFA 23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
artículos
Título:
Structural and dynamic characterization of solid furosemide polymorphs by NQR and NMR methods
Autor/es:
A. WOLFENSON; S.C. PÉREZ; M. ZURIAGA; J. ABRAHAM-MIRANDA; C. GARNERO; M. LONGHI; S. FAUDONE
Revista:
CHEMICAL PHYSICS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 641 p. 163 - 168
ISSN:
0009-2614
Resumen:
The temperature dependence of NQR parameters spin-lattice relaxation times of furosemide in forms 1 and 2 are reported. The NQR line sharp shows that form 2 is disorderer, even at low temperatures an reorientation of the SO2NH2 group between conformers has been detected above 120 K. Through T1H measurements a transition of form 2 to the high temperature phase of furosemide is observed around 405 K. The high temperature phase is characterized by one NQR line indicating Z=1 in this phase. Proton transfer and NH2 jumps in form 1 are also observed through T1Q measurements.
