UNITEFA   23945
UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Unidad Ejecutora - UE
artículos
Título:
Determinación de propiedades fisicoquímicas de Nistatina comercial empleando técnicas de caracterización de materiales
Autor/es:
GABRIELA LESCANO; SUSANA PETIGROSSO; JUAN LLABOT
Revista:
Revista Mexicana de Ciencias Farmacéuticas
Editorial:
Red de Revistas Científicas de América Latina y el Caribe, España y Portugal Sistema de Información Científica
Referencias:
Año: 2014 vol. 45 p. 31 - 36
ISSN:
1870-0195
Resumen:
Nystatin is a polyene antibiotic applied on the treatment of topical fungal infections. It can undergo auto-oxidation and thermal degradation and has three known polymorphs called Type A and Type B, which may be interconvertible, and Type C. Previous studies related to the incorporation of Nystatin in bioadhesive lms have revealed the presence of polymorph Type C, whereas the results presented in this work, obtained using a dierent lot, evidenced the presence of only polymorphs A and B with a signicant proportion of amorphous phase. To overcome the lack of uniformity between individual commercial Nystatin lots, an adequate physico-chemical characterization is necessary performing prior using it in preformulation works. Solid state characterization techniques were employed.