Improving delivery systems through supramolecular complexes of β-cyclodextrin and furosemide polymorphs

C. GARNERO; A. CHATTAH; M. LONGHI

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014 vol. 95 p. 139 - 145

0731-7085

In this work, complexes of -cyclodextrin and the two solid forms of furosemide were prepared andcharacterized for their potential pharmaceutical applications, with the interactions between the twocompounds being studied in the solution and solid states. The solubility studies revealed different behav-iors of the polymorphs. In particular, it was observed that the binary complex significantly increased thesolubility of furosemide form I in the gastric simulated fluid, which resulted in a rise in the bioavailabil-ity of this formulation after oral administration. In addition, results using ssNMR, FT-IR, DSC, TGA, SEMand XRPD provided evidence of the formation of complexes after utilizing kneading and freeze-dryingmethods. A comparison with previous developed complexes that used maltodextrin as the ligand wasperformed. Our results suggest that these novel supramolecular complexes showed promise to be usedin drug delivery systems with an application in pharmaceutical formulations.