Insights into Novel Supramolecular Complexes of Two Solid Forms of Norfloxacin and beta-Cyclodextrin

A. K. CHATTAH; K.H. MROUE; L.Y. PFUND; A. RAMAMOORTHY; M. R. LONGHI; C. GARNERO

JOURNAL OF PHARMACEUTICAL SCIENCES

JOHN WILEY & SONS INC

Lugar: New York; Año: 2013 vol. 102 p. 3717 - 3724

0022-3549

The solid state properties of novel complexes of B-cyclodextrin and two different solid forms of Norfloxacin were investigated at the molecular level, in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. These solid supramolecular systems were characterized using a variety of spectroscopic techniques including natural-abundance 13C cross-polarization magic-angle-spinning (CP-MAS) nuclear magnetic resonance (NMR), powder X-ray diffraction (PXRD) and Fourier Transform-Infrared spectroscopy (FTIR), evaluating the physical properties inherited from the different polymorphs. The intrinsic proton spin-lattice relaxation times (1H T1) detected in 13C CP-MAS NMR spectra are used to confirm and distinguish the complex formation, as well as to give insights into the molecular fragments that are involved in the interaction with B-cyclodextrin.