IIBYT   23944
INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of central administration of Coriandrum sativum essential oil on anxiety-like behavior in chicks.
Autor/es:
SOLEDAD GASTÓN; CID MARIANA PAULA; VASQUEZ ANA; AYMAR LEANDRO; NANCY ALICIA SALVATIERRA
Lugar:
Cordoba
Reunión:
Congreso; 3° Reunión Internacional de Ciencias Farmacéuticas - RICiFa 2014; 2014
Resumen:
Coriandrum sativum ("cilantro") is annual herb with culinary use and one of the main species exported from Argentina. Coriandrum essential oil (CEO) is an aromatic complex mixture of volatile substances and has antibacterial, antifungal and antioxidant activity. It also has anxiolytic and antidepressant effects when it is systemic administered. Linalool is a volatile monoterpene and the major constituent of essential oils of several plant species, including Coriandrum sativum. It was observed that its inhalation has anxiolytic and sedative effects. Numerous studies have attempted to elucidate the action of essential oils and aromatic species on the central nervous system, however few studies shown the effect of central administration of these compounds on the behavior. The aim of this study was to investigate the effect of CEO centrally administrated on anxiety-like behavior in chicks of 4-7 days-old. To evaluate the anxiety-like behavior, each animal was exposed to an open field test for 10 min. Thus, the latency to ambulate, the number of ambulations and the latency to defecate are indicators of change in the anxious-state of the animal. CEO and linalool were diluited from pure oil and administered intracerebroventricularly at concentrations of 0.1; 0.01 and 0.001 ml/chick. We observed that CEO significantly increased the ambulation latency and decreased the number of ambulations in the Open Field test at doses of 0.1 and 0.01 ml/chick. In addition, no significant increase was observed for the latency to defecate. Furthermore, linalool significantly decreases the ambulation latency and the number of ambulations at doses of 0.1 and 0.01 ml/chick. It also produced a decrease in the latency to defecate, that was only significant for the dose of 0.01 ml/chick. CEO exerts an anxiogenic-like action when it was administered intracerebroventricularly in chicks exposed to a stressor. However, this effect not due to linalool, the majority component of CEO, which has an anxiolytic-like effect. Therefore, another compound of CEO could play a stronger action on behavior than linalool.