IIBYT   23944
INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Unidad Ejecutora - UE
capítulos de libros
Título:
Role of the Neuropeptide Angiotensin II in Stress and Related Disorders
Autor/es:
BREGONZIO, C.; MARINZALDA, M.;; BAIARDI, G.
Libro:
Psychiatry and Neuroscience Update
Editorial:
Springer International
Referencias:
Año: 2015; p. 89 - 99
Resumen:
Angiotensin II (Ang II) was described as a peripheral hormone;its synthesis and metabolism were characterized and it is currentlyknown as the renin-angiotensin system (RAS). All the componentsof the RAS, including the receptors, have been found in brain tissue,indicating a role as a hormone or neuromodulator in the central nervoussystem. Ang II exerts its principal known actions at the AT1 receptor.Its functions related to AT2 receptors are controversial and associatedwith AT1 opposite effects, although there is evidence showing cross-talk between both receptors. The metabolism of Ang II generatesother active peptides, such as Angiotensin 1?7 and Angiotensin IV,which will not be discussed. Neurobiological research has explainedmany of the different neuroendocrine and behavioral responses tostressors. Stress is a complex phenomenon in response to physical,environmental, or psychological stimulus. Stress triggers importantadaptive functions improving health and survival. Meanwhile,excessive stress can be deleterious, therefore, individuals unable tocope with stress are highly vulnerable to a variety of diseases. Stressis a major contributor of cardiovascular disorders and psychiatricillness such as anxiety and depression. Many studies have confirmedthat stress also increases the vulnerability to drug abuse.The role of Ang II at the periphery and in the central nervous systemis vast and complex. For this reason, in this chapter we will focuson the role of brain RAS in stress responses and related pathologiesfrom many other important aspects of Ang II research.