IIBYT   23944
INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
MODIFICATION OF CARDIAC BIOMARKERS SENSITIVITY IN HYPERTENSIVE PATIENTS TREATED WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITORS IN ACUTE CORONARY SYNDROME WITH NON?ST SEGMENT ELEVATION
Autor/es:
JOISON, A.N.; BARCUDI, R.; BAIARDI G.
Revista:
Journal of International Research in Medical and Pharmaceutical Sciences
Editorial:
International Knowledge Press.
Referencias:
Lugar: Mancester; Año: 2019 vol. 14 p. 39 - 46
ISSN:
2395-4477
Resumen:
Background: Patients with non-ST segment elevation myocardial infarction and the mortality risk is associatedwhen Creatine Kinase isoenzyme MB and Troponin I values are increase.Objective: The present study was oriented to study the modification of cTnI and CK-MB sensitivity in thearterial hypertension and its association with drugs in the antihypertensive treatment.Methods: A descriptive and random study included 35 hypertensive patients of both sexes, admitted to thecoronary unit of the ?Reina Fabiola ?Clinic?. The patients were stratified without associated pathologies(Control group), n = 13; and with only hypertension, n = 22 treated with angiotensin-converting enzymeinhibitors (n= 15), beta-blockers (n = 7). Samples of blood were collected and cardiac markers analyzed at theentrance to the coronary care unit (0 hs) and after 8, 12, 24 hs.Results: Creatine Kinase MB activity decreased at 8 hs and Troponin I sensibility showed a decrease inhypertensive patients treated with angiotensin-converting enzyme inhibitors respect control group at 0 hs.Optimal cut points of CK-MB were 13.50, 17.00, 19.50 and 14.00 UI/L, and to cTnI 0.08, 0.17, 0.16 and 0.42ng/ml at 0, 8, 12, and 24 hs respectively.Conclusions: The remodeling and ventricular hypertrophy states are conditions that could be modifybiomarkers levels and sensitivity by the use of antihypertensive drugs. We propose an algorithm incorporatingchanges in cTnI levels and CK-MB activity to increases the diagnostic sensitivity in AHT patients.